From: "Guardado por Windows Internet Explorer 8" Subject: Genentech's Vemurafenib Meets Primary Endpoints In Phase 3 Study - Quick Facts Date: Mon, 20 Jun 2011 11:46:35 -0430 MIME-Version: 1.0 Content-Type: multipart/related; type="multipart/alternative"; boundary="----=_NextPart_000_0000_01CC2F3F.B5495970" X-MimeOLE: Produced By Microsoft MimeOLE V6.1.7600.16807 This is a multi-part message in MIME format. ------=_NextPart_000_0000_01CC2F3F.B5495970 Content-Type: image/gif Content-Transfer-Encoding: base64 Content-Location: http://www.rttnews.com/Images/PremiumServices.gif R0lGODlhfQASAPcAAMRpAPLKsNZzAOrMsMNTAOOygNd4ANdIAOircMRLANeIAMxCAOKrgOSLUPXV wNY7AOupgOF5QPrs4OutgO7SwNaDANdAAL0+ANm4ut3d7uWsYMw8ALo+AMpYENykgMmBQMt2QLhJ ANZ6ALZUAP328LZRALlaANt0IOmicNloJMpsAPDCoOGKQNdEAPLRsOWkYMx5aM1UANdMAMM1AMtL AO68kNdgAN+BMNc+ALwyANaSUNdDANdVANvI0LhOANdcAPHZwOaaYMJaAOCFQNdvANpsEMJkAPbq 4N17MOXCoMxtALdZAN2iYO3UwOF/QNdQAOW8oPXawL1MAMl9QOKykN2JUPrq4LlFAOCaQOu6gOq2 gPLe0OSlcNmKQPPh0LpCAOrEoPjl0Mp6QLhWAM2IUPz18MpZANp5EN+KMNdqAOGRQNdkANZZAL1D AN2pgL9IAPTi0NZGAOSUUOu+gOOdUPjh0O7AkNpyEME8AOK6kMBtINupgLw2APv08NqCEO/YwL00 ALxLD9FFALdNAL5REMFBAMo3AMU+AN90MLw4ANqLa/XYwLhSAMZnML9FAPDIoN9uMNpZEL9iALxg APfk0PXdwMQ5ANZOAMqAML1EDdpkEMJFAME4AMdBAL84AMp/MNedYMhrANSPYL9hAPC+oLw7AOqw gNx8INE6ANVxALxiAMVGAP///9aHANZ/ANeAANd8ANeGANZ3ANaEALs6ANeHANd3ANZLANc8ANZ8 ANeEALlBANd9ANZ9ANd/ANdzANZ+ANeBANV2ANaBANeLANd+AL80AO3WwLs3ANyMINQ+ANNMALtg AL1PANQ6ANyBINagcNZtCNqQcsVWNO7XwN+1kNFzQNd0AtRDAMt8INRLANFCAOmdcNJwAL80B9+Z YNBuANZoBME6EtNQAL9DEdB+IM9wANdwObw6A788ANZjFddrF9GSYL82AOungMNHI8JZIN2wgLxU AM1oENFzENJKAO21kMVzMNY5AOHe8e7UwN2tgOSmUNysgNd2ALlCACH5BAAAAAAALAAAAAB9ABIA AAj/ADNkUBQtVytirWopSKigYauFrSI2JLYQ4sNatR4qwBgRo0KFEEFmrCgxokaIFTNi3JjxoMmE F1W23PiSJkOENWF2vLYOg8AMKWZVGBpLaIVZsXTFOqoL6SyhT5U21VVBl9KhFZYSzZpV69NZUpNW Lfq0KtWjZZXGWpsUatK1Qs8WXUrWKdmlQukafTpXbKxe0ga+cvUK2KtXvoIRJqzYlePHg30NG/ZK 8eDLwAgf9nW4syvOiikHezXM1WjFiT+7ylwasuNgwDgDM+x48GdfqzPXdsz58GLCwwwfNozbse7P tnqE4wWLF69csKJjmUN9Dj9evURoz8UcVrHu0WH1/yoWvryGOcnCd+eePRd3772ywxIhPpef83M0 9GLeyz0s98VAV96A5yWTiwi9/Pdcc/E12Jxz0LkHXnjn/CLLhQYYIIstBmTByocfusChARxeuKGJ JZ4oi4YYVsIKFiyyaAuGHNpiI4YrkuhHGCCyksWGGWY4IomyCEOiLcIIU6SLWKRY4og5kiikjUEW KQySwqijwpZcKqEEOB5WkoUdH6Lhzy9ooinALwKsyWYq5iixZShcqsCEFuXUSacKSnSz5p9pqrmm BqyEQYeHJJxxZpptgqNCKABEKqmkTBSQTSihKJGKmmz+6eanvyiB6aSRdiDJqZKMouqpBbCiBRFE RP/BCgIvROECK1EQ8YIEErxwBhF2RMEEr6AMwAocn0iSxx+ffEINKKN88kceRgABxAskSKCGrJT8 CisRCLBCiRrgavEMEWq4QIId5zIBhLFe/JHEJJPEQ40Oy2KiCiZgiEsHrLVKoMWvaDxCAgku0GOE JJMwQ68qzDDTwRJLmECxxRXvwwoYXbxQBitqaAHiI4+wki2uachKghcfHnEEKwMscQwrH3zASj9L 2HyMCR9KQEnPErBSQxpEp3EHCT3bcUoaanyo8imtfpjEx3osQfXMNX8IB9JoiEzCzxKkcesjsoIx igkYU0wxISO0PcIYb7/dT4/iFmEKK3WssQbSN+z/zcoasuogxId62NzECE3QbPMeIxg+xoddnPBh ESywsojemLNw64cknFCD0GusMOvdXsBdDSvQkAEz4jTvwUoSQnBRAwt1sCLHGkHfELQLCMgxjxBw u+12IIwwUsLxxh/vuj4MMMBFETbcbYoNNtDNyhCLsIKEGR8yMgUrTTCS+BTf71HC9+F/KAT3rNgw hOXUU4/EEEWcEATSQWTfoyl3MyAPI/dgxRagwAp2iI8VU0icGwhgBupZjwVyABEJvkGAMSTveMcL xCB8sEEfcHCDHmCFG5pBgBiw4QcTYMUEfvCDoAVhCBNogCYcwIofxOBDzRAD+HyQODHocACDUF0T /3zwoRJ+iA3vcwAL2cAGGk7ghKKbQApXMIQgBOEEKWQAAZrhgy2wogxl8GAPqcAKKjSjCitoAA1R MAQUyBAJQUBB9sqwRQ8OooODCEQI9shHPobQA1KQAgHGwQMIsAICPOCB6AJgD1ZIgAc0TOSHpAAC VlAgBBRgBQgq2QcPePGSH0rADVnBAyewwgGJTKQhWREAGrLCCaYsAwSC5gRDQiABgRTFh6Cwx0yC QJdloMLHnIACvBWzDIj4GASKaQVcSqGPe8zEFaZJTWr+8QpvSAANxmHLJzwBEVb4UBmccAkaejOU laTAFXxJCC+ygoDq/NAbaPChJ5jSAd58wiWeEP+AHnFDn6QAkTsuYUsaJOANhPhQI6bpyyt44GWs IMUTIlG7LzbgCQ0IJyusUIWDVpOameDAF3YxUpLu4qRf+McX2tCGVdDgFjCVgUwvEQFIXOIWMoAp TmWgDRpsYhNfCCpJg9oIeJx0qG3YxCrqgdNLyFSnTpVBCiIQAZzqFBIRiMQtbprTZfjUESU1KUpX ao0O7PQWVN3qVmUACZsuYxUsHapQyYEODtj1rni16wUuUIhOCOIAgA2sYA8QB8AW9gCC6EQh9prX xnKAr34dbBwOO1jBHnaylk3sYh2r10IsILCXNaxgNXuBxk4DBrRIrWpXq9pSpOMQG9jGDmZrgR33 tGC2LcitbXW7g20cAg/pKAVraSHc1JaiFHg4xAJmy1wL3LYFtc2tdJ9r2x0417rPXcBvi8vd1L62 E7a97nVvW90dYKMTwGVtInqQgXckIhF8eG984TtfPniCE5bYgAX2y18L4MC/AO4vDjZgiXZ4Yr7v he97kZEIT3giv/2NsIQnPGFlEJgT8UUGHxjc4Afr978U5q+FMZxg+MIgA/nIAAy8kQNAuBgQLc5B jAFhjBkYAhUPwEWOH8BjHe/4x7hwhiFmMIMZw/jFL66xIZzhYx07uck87vED8BHlKvsYFUM+couT bGMgO1nKPh6yMVycA3H4JAMBAQA7 ------=_NextPart_000_0000_01CC2F3F.B5495970 Content-Type: application/octet-stream Content-Transfer-Encoding: base64 Content-Location: http://ad.doubleclick.net/ad/invc.rttnews/textlink;kw=;kval=textlink;tile=6;sz=234x20;ord=123456789? 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Genentech's = Vemurafenib=20 Meets Primary Endpoints In Phase 3 Study - Quick Facts
6/5/2011 1:09 = PM ET=20

(RTTNews) - Genentech, a member of the = Roche=20 Group (RO.SW: News=20 ,ROG.SW: News ,RHHBY.PK: News ) Sunday said the Phase III study of = vemurafenib=20 significantly improved overall survival in people with previously = untreated BRAF=20 V600 mutation-positive metastatic melanoma, compared to = chemotherapy.

Vemurafenib, a BRAF-inhibitor, is a personalized investigational = medicine=20 designed to specifically inhibit the activity of the mutant BRAF protein = that is=20 found in approximately half of all cases of melanoma, the deadliest and = most=20 aggressive form of skin cancer. The BRAF protein is a key component of = the=20 RAS-RAF pathway involved in normal cell growth and survival.

In the study, the risk of death was reduced by 63 percent for people = who=20 received vemurafenib compared to those who received chemotherapy.

In addition, vemurafenib significantly reduced the risk of the = disease=20 getting worse, a co-primary endpoint, by 74 percent compared to=20 chemotherapy.

"We are greatly encouraged by the results of BRIM3, which showed that = vemurafenib not only extended life and reduced the risk of disease = worsening,=20 but also led to significant tumor shrinkage, an important result for = this=20 devastating cancer," said Hal Barron, chief medical officer and head, = Global=20 Product Development.

=
To = receive FREE=20 breaking news email alerts for Roche Holding AG and others = in your=20 = portfolio

by RTT Staff Writer

For comments and feedback: contact=20 editorial@rttnews.com

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o=3Dd.ce("script"),head=3Dd.gn("head")[0]||d.documentElement;o.setAttribu= te("type","text/javascript");o.src=3D(_196?"":_atr)+name;head.insertBefor= e(o,head.firstChild);_7.jlr[name]=3D1;return o;}return = 1;},jlo:function(){try{var a=3D_7,al=3Da.lng(),aig=3Dfunction(src){var = img=3Dnew = Image();_7.imgz.push(img);img.src=3Dsrc;};a.alg(al);if(!a.pld){if(a.bro.i= e6){aig(_atr+a.spt);aig(_atr+"static/t00/logo1414.gif");aig(_atr+"static/= t00/logo88.gif");if(window.addthis_feed){aig("static/r05/feed00.gif",1);}= }if(a.pll&&!window.addthis_translations){setTimeout(function(){a.pld=3Da.= ajs("static/r07/menu76.js");},10);}else{a.pld=3Da.ajs("static/r07/menu76.= js");}}}catch(e){}},ao:function(elt,pane,iurl,_1a1,_1a2,_1a3){_7.lad(["op= en",elt,pane,iurl,_1a1,_1a2,_1a3]);_7.jlo();return = false;},ac:function(){},as:function(s,cf,sh){_7.lad(["send",s,cf,sh]);_7.= jlo();}});(function(_1a7,_1a8,env){var = d=3Ddocument,_1ab=3D1,_1ac=3D["cbea","kkk","zvys","phz"],i=3D_1ac.length,= 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